In conventional metallic materials, the increase of strength by dislocation hardening generally sacrifices ductility. In recent years, a novel alloy design concept has drawn great attention, where multi-principal elements are mixed at equimolar or near equimolar concentrations to form highly concentrated solid solutions, termed high-entropy alloys (HEAs). To promote the wide use of HEAs as structural materials, it is highly desirable to improve the strength of HEAs while maintaining good ductility. In this project, we demonstrate an approach to improve the strength and ductility simultaneously by tuning the stacking fault energy and deformation mechanism in single-phase face-center cubic (FCC) high-entropy alloys (HEA) as shown in Fig. 1.